LONDON, England: Grade III furcation defects represent one of the most challenging scenarios in periodontal care, and robust evidence to guide their treatment remains scarce. To address this gap, a feasibility study has explored an innovative, adaptive trial design to assess outcomes in treating these lesions. Using a sequential, multiple assignment randomised trial (SMART) approach, the researchers aimed to determine whether a dynamic, responsive treatment pathway could improve both clinical and patient-reported outcomes.