ŌTSU, Japan: The links between diabetes, obesity and periodontal disease are well established; however, most studies on their associations have had sample sizes of fewer than 10,000 participants. This limits robust analysis of these and other risk factors of tooth loss. A narrative review by researchers at Shiga University of Medical Science in Ōtsu has leveraged large-scale national data to assess the impact of diabetes and obesity on tooth retention, offering clearer insights into the cyclical relationship between the conditions in relation to tooth loss.