LONDON, England: Although periapical periodontitis can increase systemic inflammation and is associated with cardiovascular risk and impaired glycaemic control, the relationship between endodontic therapy and improvements in metabolic health had not been previously explored. A pioneering clinical study at King’s College London has now investigated changes in serum metabolites after root canal treatment and found that it was associated with significantly reduced inflammation and with improvements in blood glucose and cholesterol levels, underscoring the systemic health benefits of effective dental care.